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Whilst GLP-1 receptor agonists are not diuretics and do not typically cause polyuria, several factors associated with treatmentincluding improved glycaemic control, weight loss, and gastrointestinal effectscan influence urinary patterns
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However, this effect might be independent of changes in visceral fat accumulation since previous studies have demonstrated that the hepatic glucose production is decreased in healthy individuals following acute administration of both native GLP-1 ( de novo lipogenesis and reduces levels of lipolysis-induced FFA and triglyceride-derived toxic metabolites ( Insulinotropic effect As alluded above, patients with NAFLD, in whole its spectrum including cirrhotic individuals, show a reduced incretin effect
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