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Nat Rev Genet 9(2):102114
Serotypes such as AAV1, AAV6, AAV8, and especially AAV9 have demonstrated efficient cardiac transduction in small and large animals, enabling robust gene transfer to myocardium with intracoronary or intravenous delivery (Mazurek et al., 2024)
The design of the capsule formulation provides assurance for the intestinal absorption of IGF-1 LR3: The protective effect of capsule shell IGF-1 LR3 capsules often use hydroxypropyl methylcellulose (HPMC) capsule shells, which are insoluble in the stomach (pH 1-3) and can protect IGF-1 LR3 from gastric acid damage
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