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"Glucagon-like peptide-1 receptor activation maintains extracellular matrix integrity by inhibiting the activity of mitogen-activated protein kinases and activator protein-1." Free Radic Biol Med

Amgen's MariTide Phase 2 showed no weight loss plateau at 52 weeks (Nov 2024): The absence of a weight loss plateau effect which both semaglutide and tirzepatide display would be a clinically meaningful differentiation if confirmed in Phase 3, potentially enabling greater sustained weight loss

Warning signs include shakiness, sweating, confusion, rapid heartbeat, dizziness, or extreme hunger

Semaglutide has a longer track record and an oral formulation