Liver normally clears vasodilators (nitric oxide) from portal blood
Yes, switching is possible, but it should only be done under a doctors guidance
redrag Sikiri, Sven Seiwerth, eljko Grabarevi, Rudolf Ruman, Marijan Petek, Vjekoslav Jagi, Branko Turkovi, Ivo Rotkvi, Stjepan Mie, Ivan Zorii, Pako Konjevoda, Darko Perovi, Ljubica Jurina, Jadranka eparovi, Miro Hanevaki, Branka Artukovi, Mirna Bratuli, Marina Tiljar, Miro Gjurain, Pavao Mikli, Dinko Stani-Rokotov, Zoran Slobodnjak, Nikola Jelovac, Anton Marovi, The influence of a novel pentadecapeptide, BPC 157, on NG-nitro-l-arginine methylester and l-arginine effects on stomach mucosa integrity and blood pressure, European Journal of Pharmacology, Volume 332, Issue 1, 1997, Pages 23-33, ISSN 0014-2999, Seiwerth S, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, Drmic D, Stupnisek M, Misic M, Vuletic LB, Pavlov KH, Barisic I, Kokot A, Japjec M, Blagaic AB, Tvrdeic A, Rokotov DS, Vrcic H, Staresinic M, Sebecic B, Sikiric P

If your BMI is 27 or higher and you have high blood pressure, type 2 diabetes, or high cholesterol, semaglutide may be appropriate even below the obesity threshold