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Long-term exposure to pro-oxidants causes oxidative stress, which affects cellular structure, mitochondrial DNA, and functioning enzymes
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GSH is synthesized from glutamate, cysteine, and glycine catalyzed by glutamate cysteine ligase (GCL) and glutathione synthetase (GSS) and involves in the regulation of ferroptosis (Kalinina and Gavriliuk, 2020
The results showed that JYTLD improved renal function by inhibiting ROS production and regulating mitochondrial dynamics, alleviating renal tubulointerstitial fibrosis (TIF), and enhancing mitochondrial function
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