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The GLP-1R are expressed in tissues other than pancreatic islets 24 , as in hepatocytes, but studies suggest that certain actions of GLP-1 in hepatic glucose metabolism occur through mechanisms that are independent of GLP-1R, and no alternative route seems to have been fully elucidated 25
Similarly, a change in bowel habit lasting more than 6 weeks in people aged 60 or over should be discussed with your GP, who may arrange tests such as a full blood count or faecal immunochemical test (FIT)
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