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Through studies of mice and rat models, it has been determined that PPG neurons contain projection tracts to various locations on the brain, including primarily the hypothalamus, supraoptic nucleus, and autonomic regions such as the limbic forebrain, portions of the mesolimbic reward system, and other regions involved in learning and memory [47, 50]
Advice to Patients Inform patients that tirzepatide causes thyroid C-cell tumors in rats and that the human relevance of this finding has not been determined
Retrieved October 11, 2021 from Antonio, J., Candow, D
The article says the mechanism is direct: GLP-1 receptor activation in the chemoreceptor trigger zone and brainstem intensifies nausea signalling
