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In type 2 diabetes, tirzepatide was noninferior and superior to semaglutide for mean HbA1c change at 40 weeks (Fras et al., 2021), and a network meta-analysis found tirzepatide 15 mg to be the most efficacious regimen for HbA1c reduction at 21.61 mmol/mol [1.96%], followed by tirzepatide 10 mg at 20.19 mmol/mol [1.84%], semaglutide 2.0 mg at 17.74 mmol/mol [1.59%], tirzepatide 5 mg at 17.60 mmol/mol [1.60%], semaglutide 1.0 mg at 15.25 mmol/mol [1.39%], and semaglutide 0.5 mg at 12.00 mmol/mol [1.09%] (Karagiannis et al., 2024)
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95% CI: 0.79-1.39) and 4-point MACE (meta-analytic HR: 0.95
Eur Endocrinol
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