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Research shows that weight regain is common when GLP-1 medications are discontinued without proper support
First, the trial ran for a long 72 weeks , which matters because incretin-driven weight loss accrues slowly and the curves in these studies keep descending for a year or more before flattening
The key to a longer life, he realized, was keeping chronic disease at bay
A separate study published in August 2025 found patients prescribed semaglutide or tirzepatide for Type 2 diabetes had an increased risk of NAION and other optic nerve disorders, but the overall risk was very low
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