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Efficacy and safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial

In the semaglutide trial, treated adolescents showed significantly larger declines in glycated hemoglobin (HbA1c), fasting glucose, waist circumference, triglycerides, LDL-cholesterol and alanine aminotransferase than placebo (10)