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No serious adverse events organ failure, severe allergic reactions, or deaths have been reliably documented in the peer-reviewed literature at typical research doses

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European Journal of Anaesthesiology (2001) Related Dosing Protocols Written by Garret Grant Founder & Lead Researcher B.S

The trade-off is that higher doses later in your protocol will require drawing larger volumes, potentially exceeding the 100-unit syringe capacity at doses above 1mg to 2.5mg depending on concentration