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Historical Background and Scientific Context Scientific interest in peptide signalling compounds expanded significantly during the late twentieth century as advances in peptide chemistry enabled researchers to investigate increasingly complex molecular communication systems
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Animal models have also identified interaction pathways between the brain and adipose tissue, as well as between the brain and the microbiota, indicating that peripheral events strongly influence central nervous system activity and behavior ( The complex etiopathogenesis of T2DM has been explored in detail and includes insulin resistance (in the liver, muscles, and adipose tissue), impaired insulin secretion, -cell dysfunction, immune dysregulation and meta-inflammation, hyperglucagonemia, disrupted gut microbiota, increased gastric glucose absorption, renal adaptation with enhanced glucose reabsorption and gluconeogenesis, decreased dopamine, and heightened sympathetic tone in the brain ( via cells of the circumventricular organs located around the third and fourth brain ventricles, transmitting signals to deeper brain structures
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