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Gallo G (2024) Neuronal glycolysis: focus on developmental morphogenesis and localized subcellular functions
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After oral ingestion, NAC undergoes significant first-pass hepatic metabolism
Comprehensive in vivo safety evaluation including hemolysis testing, blood biochemistry, body weight monitoring and histopathological examination of major organs showed no significant toxicity, while pharmacokinetic profiling revealed prolonged circulation half-life and enhanced bioavailability compared with free doxorubicin, confirming that the folate-targeted chitosanMOF platform successfully translated high drug loading, receptor-specific uptake and controlled release into improved therapeutic performance with acceptable safety margins [115]
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