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As weight is lost, the body adapts (metabolically) and requires fewer calories to support a lower weight, Dawkins says

If you are into chemistry (if not, we understand, just skip this paragraph), the reason is that electrolytes (you know, the Na+ and Cl- ions) screen the electrostatic repulsion between the head groups of ionic surfactants and thus support the formation of long shaped micelles (instead of spherical ones) that entangle like spaghetti, and viola, a gel is formed

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That's the premise behind Lipo-C, one of the most widely used lipotropic injections in weight loss clinics across the country