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It should be particularly noted that the IDO-mediated shift of TRP metabolism towards the KP is a key mechanism linking epilepsy with comorbid depression

Costa and Stevenson (1984) with the administration of equine chorionic gonadotropin (eCG) and pregnant mares serum gonadotropin (PMSG) showed that these components increases ovarian concentration of free LC and ALC, which shows the interaction between the direct and indirect mechanisms through cellular and hormonal regulations [82]