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This multi-receptor profile is why comparative in-vitro studies group it separately from single-target (GLP-1R only) or dual-target reference peptides

A peptide that modulates VEGFR2 in a cell culture dish, or heals a rat tendon at 10 mcg/kg IP injection, has not been shown to survive oral delivery in a human at 500 mcg and reach musculoskeletal tissue at any meaningful concentration

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Two complementary mechanisms (collagen/angiogenesis + actin-mediated cell migration) targeted at soft-tissue and joint healing