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In the STEP UP clinical trial, the 7.2-mg dose demonstrated a mean weight loss of 20.7% at 72 weeks, compared with a reduction of 17.5% with the previously approved semaglutide (Wegovy) injection (2.4 mg) and 2.4% with placebo

The decision should account for the approved work plan, expected use, storage controls, record rules, and waste

ABBREVIATIONS: ADE adverse event AUD alcohol use disorder CHOP C/EBP homologous transcription factor protein ER endoplasmic reticulum GI gastrointestinal GLP-1 glucagon-like peptide-1 GLP-1 RAs GLP-1 receptor agonists GRP78 glucose regulatory protein 78 HbA1c hemoglobin A1C PD Parkinson disease RIC remote ischemic conditioning T2DM type 2 diabetes mellitus

Comparison of valproic acid vs