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& Crowther, R
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The result is a synergistic GH secretion profile that neither compound achieves in isolation, combining GHRH-receptor-driven cAMP/PKA somatotroph amplification with GHS-R1a-mediated intracellular calcium mobilisation for a physiologically pulsatile, dual-pathway GH response
Older adults may respond differently to therapy and may need closer monitoring, particularly if they have other endocrine, metabolic, or cardiovascular conditions
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