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In an in vivo study, the acute treatment with GLP-1 in female rats resulted in the increase of the amplitude of the preovulatory LH surge, likely by the activation of the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons [35]

This helps explain why many people taking GLP-1 medications report significant reductions in their desire to eat, especially high-calorie or sweet foods

Scenario 1: In Vitro Pituitary Cell Culture Study One of the cleanest ways to see this blend in action is with an in vitro study

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