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In rodents, ID, with or without anaemia, decreased serum T4 and T3 concentrations, lowered 5-deiodinase (DIO) activity and reduced the ability to thermoregulate in response to a cold environment ( Reference Hess, Zimmermann and Arnold 39 , Reference Beard, Tobin and Green 51 Reference Beard, Finch and Green 53 )

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This occurs when there's an imbalance between the generation and buildup of reactive oxygen species (ROS) within cells and tissues and the ability of innate biological systems and dietary antioxidants to eliminate these reactive byproducts