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Found in key areas of the brain, these receptors play a vital role in suppressing hunger, reducing food intake, and enhancing fat utilization
3.3 Mitochondrial dysfunction and oxidative stress Chronic hyperglycemia in patients with T2DM leads to peripheral insulin resistance, whereas impaired insulin signaling pathways in the brains of patients with AD lead to brain insulin resistance, both of which are closely related to mitochondrial dysfunction and OS (Zhang et al., 2023)
1 Introduction Glucoraphanin (GRP) is a naturally occurring sulfur-containing compound mainly produced by cruciferous plants such as cauliflower, broccoli, radish, cabbage, arugula, kale, bok choy, Brussels sprouts, collards, and watercress
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