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These brain cells rely on glycolysis in energy generation and produce lactate, which serves as both main energy fuel and a signaling molecule for neurons
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9, show increases in mitochondrial mass and signalling
Given these high rates of adverse events, and an as yet unverified adverse event signal of suicidal thoughts and self-injury [49, 103,104,105] (albeit with some recent contradictory evidence [106]), it is not advisable that GLP-1 receptor agonists be administered without proper medical consultation
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