We demonstrated that, although ROS are necessary for the initiation phase of ATG, the modulation of thiols are fundamental for the progression of starvation-induced ATG ( Figure 2 )
GSH deficiency results in the activation of von Willebrand Factor (Ibrahim et al., 2004) and in the accumulation of ROS, which affect clotting and platelet activation, impair endothelial function, and predispose to the risk of thrombotic events (Violi et al., 2017): notably, hypercoagulation is a prominent life-threatening complication in COVID-19 patients (Giardini et al., 2020)
Atluri H, Mullin J, Takahashi K, Loghavi S, Maiti A, Sasaki K, Daver N, Valero YA, Pemmaraju N, Borthakur G, Hammond DE, Chien KS, Ferrajoli A, Short NJ, Abbas HA, Jabbour E, Andreeff M , Ravandi F, Tidwell RSS, Wang X, Konopleva MY, Garcia-Manero G, Kantarjian HM, DiNardo CD
[Effect of L-carnitine in patients with ischemic heart disease]