Given that HK-2 is efficient at reducing noise-induced cell damage, it could be administered orally and it shows no side effects, at least in rats, it has been suggested as a new treatment option for NIHL (Chen et al., 2020)
10,15,91 Of current interest is estetrol, which is a natural estrogen that spares the endometrium, while being an estrogen receptor agonist in the tissues, including the skin, that deteriorate following the loss of estradiol in the post-menopausal period
Kalyoncu M, Cimsit G, Cakir M, et al: Toxic epidermal necrolysis treated with intravenous immunoglobulin and granulocyte colony-stimulating factor
For instance, pretreatment with vitamin D enhanced the cytotoxicity of doxorubicin on breast cancer cells in a laboratory study (Ravid 1999)