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This review highlights methionine as a critical amino acid in cellular and metabolic health, demonstrating that both restriction and supplementation can influence lifespan, inflammation, and metabolic function, with optimal dosing essential to balance benefits and risks

Peptide bond hydrolysis by gastric proteases remains a real degradation risk

Thiamine deficiency adversely affects the activity levels of these enzymes, with TK, through thiamine-dependent erythrocyte transketolase (ETK) activity, common biomarkers of thiamine status, since it is particularly sensitive to thiamine levels and AKD often exhibiting the earliest detectable changes (, )

Methylcobalamin is often recognized as the most bioavailable source of Vitamin B12