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Atomic-resolution structures of horse liver alcohol dehydrogenase with NAD(+) and [PMID: 22531044] Laboratory literature summary: Atomic-resolution structures of horse liver alcohol dehydrogenase with NAD(+) and fluoroalcohols define strained Michaelis complexes
Reduces Cell Damage in Liver Disease The liver is an important organ with vital roles in detoxification and metabolism
Mechanistic experiments using the PI3K inhibitor wortmannin demonstrated that PI3K/AKT signaling is required for the anti-inflammatory and anti-apoptotic effects, identifying the brain AngIV/PI3K/AKT axis as the proximate mechanism in this model
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