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Notable in this context, a low serum level of free testosterone is an independent predictor of bone mineral density (BMD) and the risk of osteoporotic fracture in elderly men [17,18,19]

For context, the GIP/GLP-1 dual agonist tirzepatide was studied in SURMOUNT (NEJM 2022) and SURMOUNT-OSA (NEJM 2024)