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The abrupt cessation of GLP-1R agonists in individuals with metabolic disorders may lead to adverse effects, as seen in a case where a patient developed IIH after discontinuing duraglutide [29]
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These medicines help regulate blood sugar and body weight by: Increasing insulin secretion when blood glucose rises Reducing glucagon release Slowing stomach emptying Increasing feelings of fullness Reducing hunger and food cravings Supporting long-term calorie reduction Some newer medicines, such as tirzepatide, also activate GIP (Glucose-Dependent Insulinotropic Polypeptide) receptors, further enhancing weight loss and blood sugar control
In previous Phase 2 clinical trials, participants reported an average weight loss of about 22.8% (with an 8mg dose) and 24.2% (with 12mg) after retatrutide for 11 months
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