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Additionally, not everyone benefits equally from metformin therapy, some experience negative effects as well (DeFronzo and Goodman, 1995) and therefore the microbiome is an important part in the inter-individual variability in drug response
Intestinal Obstruction: Physical blockages that often require emergency surgery to remove portions of the bowel
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Pancreatic DPP-4 As well as influencing glucose homeostasis through its more widespread systemic effects, as discussed above, there is some evidence to suggest that DPP-4 may have local actions in the endocrine pancreas
