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While 75% or more of newborns with SCD in sub-Saharan Africa do not make their fifth birthday (McGann, 2014), in medium- to well-resourced countries almost all of affected babies can now expect to live to adulthood but overall survival still lags behind that of a non-SCD person by 2030 years (Telfer et al., 2007

Novel nucleic acid nanocomplexes, such as CpG-STAT3 siRNA conjugates (NCT04995536), were evaluated for their ability to silence oncogenic pathways and stimulate immune responses in relapsed B-cell non-Hodgkin lymphoma (NHL), although the study was withdrawn before completion

Cancer Gene Ther 17(4):1-9, 2010