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Glutathione deficiency has been correlated with weaker immune function and increased vulnerability to infection due to the liver's reduced capability to detoxify The biochemical function of glutathione Glutathione two separate forms are available, reduced glutathione (GSH, or L-glutathione), which is an active form, and oxidized glutathione (GSSG), the inactive form

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Proliferation Assay Fresh isolated PBMCs or purified T/B cells labeled carboxyfluorescein succinimidyl ester (CFSE) were cultured with different concentration of L-Cn (Sigma-Aldrich) for 5 days in the presence of soluble anti-CD3 (5 g/mL, Biolegend) and anti-CD28 (5 g/mL, Biolegend) for T cell proliferation assay or 7 days in the presence of CPG (10 g/mL, InvivoGen) for B cell proliferation assay or with medium only as control