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Research Application: AHK-Cu is of primary interest for its effects on fibroblasts, cells that are responsible for the growth and maintenance of extracellular matrix (the stuff between cells)
Rodent and in vitro studies report effects on tendon, ligament, muscle and gastrointestinal tissue, with a recurring mechanistic theme: the promotion of new blood-vessel formation, or angiogenesis
Such ligand-induced dimerization model has been observed in the activation of c-MET by a bacterial c-MET agonistInlB 31 , as well as in the activation of many other RTKs, such as PDGFR and VEGFR 32,33
Bioavailability of B12 is dependent on specific conditions in the digestive tract
