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Someone with specific MC4R or FTO variants might experience optimal appetite control with morning injections, while a different genetic signature could favor evening dosing
The article says severe diarrhea of four or more loose stools daily, symptoms persisting beyond eight weeks, or diarrhea accompanied by abdominal pain, blood in the stool, or signs of dehydration all warrant immediate provider evaluation
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With reduced preload the heart does not have to exert as much contractile force which reduces the oxygen requirements of the heart and also reduces ventricular transmural pressure resulting in reduced compression of the coronary arteries allowing for more efficient blood flow through the heart
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