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doi:10.1016/s0033-0620(97)80037-0 Fisher JS, Gao J, Han DH, Holloszy JO, Nolte LA
Androgens have been shown to downregulate the expression of bile-salt export pump (BSEP) and multidrug resistanceassociated proteins (MRPs), resulting in bile-acid retention and cytotoxic accumulation within hepatocytes
notably, metformin non-users experienced numerically higher gastrointestinal event rates
Additionally, amino acid pathways involving arginine, ornithine, and proline are tightly linked to extracellular matrix synthesis, nitric oxide (NO) signaling, and immune regulation, which may indirectly affect ferroptosis by modulating ROS production and amino acid availability (8789)
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