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In this context, upregulation of VCAM-1 and integrin 4 expression in tumor-associated LECs, due to the presence of tumor-derived inflammatory factors, leads to weakened LEC junctions, further contributing to increased lymphatic permeability and cancer cell penetration into LVs (157) ( Figure 4A )
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This maintains cell flexibility and promotes cellular motility, allowing essential repair cells to migrate through dense extracellular matrices to reach the site of study
Analysis using the Broad Institute Connectivity Map reported that GHK shifts the expression of a large number of human genes, with the direction of the shift described as resetting expression toward a healthier pattern in the cell lines tested
