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Furthermore, we observed no significant effect on mtDNA copy number in the knockout or treatment, consistent with unchanged MIC60 expression levels, which is known to play a role in nucleoid organization (Fig

This study has reported that AC could efficiently restore sinusoidal networks through targeting high-mobility group box 1/toll like receptor 3/interferon regulatory factor 1 (HMGB1/TLR3/4-IRF1) signaling to reduce inflammatory events (Jia et al