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doi: 10.1007/s00401-015-1513-1 51 VandebroekAYasuiM
Not all patients respond to GLP-1 medications in the same way, and researchers are still working to understand why some people experience little or no effect
The semaglutide cohort ( n = 1470) compared with the naltrexone/topiramate cohort ( n = 1430) was older, included more women, had a higher prevalence of severe obesity and obesity-associated comorbidities including T2DM and lower prevalence of adverse socioeconomic determinants of health, problems with lifestyle, and substance use disorders
Using the drug after this timeframe may compromise its effectiveness and safety
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