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Clinical studies have demonstrated significant reductions in trunk fat and visceral fat specifically, with less impact on subcutaneous fat and lean mass targeting the most metabolically dangerous fat depot
For context on SAMe and related evidence limits, see the NIH NCCIH resource S-Adenosyl-L-Methionine (SAMe): In Depth
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Calzada Ltd was aggressively pursuing this treatment route in the early 2010s, reporting in 2012 that AOD-9604 might promote cartilage creation and repair [in vitro] (Source)
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