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Efficacy and safety of oral orforglipron in patients with type 2 diabetes: A multicentre, randomised, dose-response, phase 2 study
Clinical trials have reported average weight reductions of approximately 3 to 5 kilograms with shorter acting agents, while higher dose, longer acting formulations have produced more substantial losses exceeding 10 kilograms in some patient populations
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Starting with a lower dose and taking it with food can help mitigate this
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