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The NAD+ decline is now recognized as a central node connecting multiple hallmarks of aging, including mitochondrial dysfunction, genomic instability, and cellular senescence
217 Throughout the progression from precancerous lesions to localized tumors and from tumors in situ to metastatic tumors, the metabolic preferences of tumor cells continuously change in response to cellular states and environmental conditions, which are regulated by endogenous signals from tumor cells and signals from the tumor microenvironment
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