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The effect on stroke is remarkable (and was significant in the trials of both semaglutide and dulaglutide), amounting to an 18% risk reduction, also because the other class of new antidiabetic agents with cardiovascular benefits, the SGLT2-inhibitors, show no a similar effect on stroke (but do have a significant effect on heart failure) [24]
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For example, a randomized, double-blind, placebo-controlled trial in patients with overweight or obesity -associated KOA assessed the effects of liraglutide (3 mg/day) over 52 weeks as an add-on to dietary guidance [47, 48]
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