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In personal communications, the researcher noted that, To our knowledge, GSH is an active substance and metabolized mostly in the small intestine

The consistency of positive outcomes across diverse animal studies suggests real therapeutic potential, while the lack of large-scale human trials means optimal protocols remain somewhat empirical

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The British National Formulary (BNF) states: For people with neurological involvement Initially administer hydroxocobalamin 1 mg intramuscularly on alternate days until there is no further improvement, then administer hydroxocobalamin 1 mg intramuscularly every 2 months