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Switching to semaglutide, which only targets the GLP-1 receptor, may offer a milder experience for some patients while still providing effective weight management support
When clinically appropriate, we can discuss FDA-approved GLP-1 medications and, when necessary and permitted, compounded formulations prepared by licensed U.S
However, this plateau phenomenon reflects normal physiological adaptations rather than true drug tolerance
Another GLP-1 agonist, Mounjaro, is prescribed by GPs in England for those with a BMI of 40 or over (or 37.5 if from a minority ethnic background) and four out of five conditions (type 2 diabetes, high blood pressure, heart and vascular disease, high cholesterol and obstructive sleep apnoea)
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