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Together these observations are consistent with an important concept: microglia are the earliest responders to a primary multifocal myelin injury in the MS white matter, and importantly, this injury/response seems to precede lymphocytic infiltration, arguing against adaptive immune cells being the primary drivers of white matter injury

demonstrated that fatty acids stimulate the expression of fatty acid-binding protein 5 (FABP5), which in turn stabilizes and activates hypoxia-inducible factor-1 (HIF-1) in liver cancer cells

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