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Inhaled forms of selective JAK1 inhibitors, such as AZD0449 and AZD4604 have been developed, and they have shown efficacy in reducing lung inflammation and late asthmatic response by inhibiting STAT phosphorylation in lung tissues [141]
Other next-generation agents, such as IPN60090 (IACS-6274), have demonstrated early signs of clinical activity and effective GLS1 inhibition in Phase I studies, with ongoing trials exploring combinations (e.g., with bevacizumab and paclitaxel)
Zhu, L., Huang, Y., Edirisinghe, I., Park, E., & Burton-Freeman, B
In contrast, powders and spices can contain as little as 2% of curcuminoids
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