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Many men review these options as part of physician-supervised mens hormone optimization, where a clinician can weigh that tesamorelin is FDA-approved only for HIV-associated lipodystrophy and that other uses are off-label

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Such mutations impair cellular uptake of riboflavin, leading to reduced FMN and FAD synthesis and consequent dysfunction of mitochondrial FAD-dependent enzymes, culminating in axonal degeneration, motor neuron disease, and sensory neuropathy