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Introduction Osteoarthritis (OA) is a prevalent age-related degenerative disease, which is characterized by degeneration of articular cartilage and damage to the other joint tissues ( OA involves oxidative stress, articular cartilage degradation, synovitis and their interplay ( OA is viewed as a multifactorial disorder with predisposition factors such as heredity, endocrine disorder, age, gender, joint biomechanics, abnormal mechanical load, weight gain, history of joint surgery and nutrition (Figure 1)

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