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In this pathway, methylcobalamin provides the methyl group that couples to carbon monoxide (derived from CO 2 ) to afford acetyl-CoA

According to the cited figure 3[14], the increase of NADPH concentration from 2,5 mM [1] up to 10 mM also increases the velocity of GR and the GSH reserve levels, that are increased from 10 mM up to 100 mM, in such a way to always saturate GP activity