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Effectiveness: Metformin can cause some weight loss, although not as much as the GLP-1 drugs

Weight loss in particular, but also cardiorenal benefits and other potential advantages, have encouraged wider use, and several further GLP-1RAs with ever longer circulating half-lives are advancing in development, aiming to leverage the convenience of administration with minimal gastrointestinal side effects (Table 2) [37]

Paeoniflorin ameliorates skeletal muscle atrophy in chronic kidney disease via AMPK/SIRT1/PGC-1-Mediated oxidative stress and mitochondrial dysfunction