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Titrate: Increase by roughly 100 mcg per dose every two weeks as tolerated
Vitamin B12 is a water-soluble vitamin, which means that excess amounts are usually excreted by the body in the urine
Habibullah, M
Strategies have been developed that enhance the ability of drugs to penetrate the BBB, including increasing drug lipid solubility, use of carrier-mediated transport, or concurrent use of another drug that disrupts BBB permeability (Mikitsh and Chacko, 2014)
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